Making Southern Meatloaf is a simple process that anyone can follow. Here’s how to do it:

1. Preheat the Oven: Preheat your oven to 350°F (175°C) to prepare for cooking.
2. Prepare the Pan: Grease a loaf pan or line it with parchment paper for easy removal.
3. Sauté Vegetables: In a skillet over medium heat, sauté the chopped onion and minced garlic until they are tender and fragrant. This usually takes around 5 minutes. Let them cool slightly.
4. Mix Ingredients: In a large bowl, combine the ground meat, breadcrumbs, milk, sautéed onion, garlic, eggs, ketchup, Worcestershire sauce, salt, pepper, oregano, thyme, paprika, and cayenne pepper.
5. Combine Mixtures: Mix thoroughly but avoid overworking the meat to keep it tender. Use your hands for the best results.
6. Shape the Meatloaf: Transfer the mixture to the prepared loaf pan. Form it into a loaf shape by pressing gently.
7. Glaze the Meatloaf: Spread a layer of ketchup over the top of the meatloaf for a sweet and tangy glaze.
8. Bake: Place the prepared meatloaf in the preheated oven and bake for about 1 hour, or until the internal temperature reaches 160°F (70°C).
9. Rest the Meatloaf: Once out of the oven, let the meatloaf rest for 10-15 minutes before slicing. This helps it retain its juices.
10. Serve: Slice into thick pieces and serve immediately with your favorite sides.

By following these straightforward steps, you’ll have a beautiful Southern Meatloaf ready to delight your family!