Creating Chicken Bubble Up Bake is easy when you follow these clear instructions:

1. Preheat the Oven: Begin by preheating your oven to 350°F (175°C).
2. Prepare the Dish: Spray a 9×13 inch baking dish with cooking spray to prevent sticking.
3. Mix Ingredients: In a large bowl, combine the cooked chicken, cream of chicken soup, frozen vegetables, milk, garlic powder, onion powder, salt, and pepper. Stir until everything is well mixed.
4. Add Cheese: Fold in half of the shredded cheddar cheese into the mixture for added flavor.
5. Cut Biscuits: Open the can of biscuit dough and cut each biscuit into quarters. This will create the “bubble” effect when baked.
6. Combine Ingredients: Gently fold the biscuit pieces into the chicken mixture until everything is coated.
7. Pour into Baking Dish: Transfer the mixture to the greased baking dish and spread it evenly.
8. Top with Cheese: Sprinkle the remaining shredded cheddar cheese on top for a gooey finish.
9. Bake: Place the baking dish in the preheated oven and bake for 25 minutes, or until the biscuits are golden brown and cooked through.
10. Cool and Serve: Once finished, let it cool for about five minutes before serving.

These steps outline how to create this amazing meal quickly and easily!