Tuscan Chicken and Spaghetti Squash

If you love creamy, savory, and comforting casseroles, this Tuscan Chicken and Spaghetti Squash Casserole is about to become your new favorite. It’s a delicious, wholesome meal that combines tender chicken, flavorful sun-dried tomatoes, nutrient-packed spinach, and roasted spaghetti squash—all brought together with a luscious garlic parmesan sauce. The result? A low-carb, high-protein dish that feels indulgent but won’t leave you feeling weighed down.

Tuscan flavors are known for their balance of rich and fresh ingredients, and this dish embodies that beautifully. Instead of using traditional pasta, we swap it for spaghetti squash, which not only soaks up all the flavors but also keeps the dish light and nutritious. Whether you’re looking for a cozy weeknight dinner, a meal prep option, or a show-stopping dish for gatherings, this casserole checks all the boxes. Plus, it’s naturally gluten-free and can be customized to fit different dietary needs.

Why You’ll Love This Tuscan Chicken and Spaghetti Squash Casserole

• Rich, Creamy, and Satisfying – The combination of a velvety garlic parmesan sauce with juicy chicken and roasted spaghetti squash makes for an ultra-satisfying bite.

• Healthy Yet Indulgent – You get all the comforting flavors of a classic creamy pasta dish, but with lower carbs and more nutrients.

• Perfect for Meal Prep – This casserole reheats beautifully, making it an ideal make-ahead meal for busy weeks.

• Naturally Gluten-Free and Low-Carb – If you’re following a low-carb or gluten-free diet, this dish is a fantastic option without sacrificing taste.

• Easy to Customize – You can switch up the proteins, add different vegetables, or make a dairy-free version with a few simple swaps.

Preparation Time and Yield

• Prep Time: 15 minutes

• Cook Time: 50 minutes

• Total Time: 1 hour 5 minutes

• Yield: 6 servings

Nutritional Information (Per Serving)

• Calories: 350

• Carbohydrates: 14g

• Protein: 32g

• Fat: 18g

• Fiber: 4g

• Sugar: 6g

Ingredients for Tuscan Chicken and Spaghetti Squash Casserole

For the Spaghetti Squash:

• 1 large spaghetti squash, halved and seeds removed

• 2 tablespoons olive oil

• ½ teaspoon salt

• ½ teaspoon black pepper

For the Chicken Mixture:

• 2 cups cooked chicken, shredded (rotisserie chicken works great)

• 1 tablespoon olive oil

• 4 cloves garlic, minced

• ½ cup sun-dried tomatoes, chopped

• 3 cups fresh spinach, chopped

• 1 teaspoon Italian seasoning

• ½ teaspoon red pepper flakes (optional, for a little heat)

For the Creamy Parmesan Sauce:

• 1 cup heavy cream (or half-and-half for a lighter option)

• ½ cup chicken broth

• ¾ cup grated parmesan cheese

• 1 teaspoon Dijon mustard

• ½ teaspoon salt

• ½ teaspoon black pepper

For Assembly:

• ½ cup shredded mozzarella cheese

• 2 tablespoons chopped fresh basil (for garnish)

Step-by-Step Instructions for Tuscan Chicken and Spaghetti Squash Casserole

Step 1: Roast the Spaghetti Squash

Preheat your oven to 400°F (200°C). Drizzle the inside of the spaghetti squash halves with olive oil, then season with salt and black pepper. Place them cut-side down on a baking sheet lined with parchment paper. Roast for 35-40 minutes, or until the flesh is tender and easily shreds into strands. Let it cool slightly before scraping the flesh into strands with a fork.

Step 2: Prepare the Chicken Mixture

While the squash is roasting, heat 1 tablespoon of olive oil in a large skillet over medium heat. Add the minced garlic and cook for about 30 seconds until fragrant. Stir in the sun-dried tomatoes, Italian seasoning, and red pepper flakes (if using). Cook for another minute.

Next, add the chopped spinach and cook until wilted, about 2 minutes. Stir in the shredded chicken, mixing well so the flavors blend together. Remove from heat and set aside.

Step 3: Make the Creamy Parmesan Sauce

In a saucepan over medium heat, combine the heavy cream, chicken broth, and Dijon mustard. Bring to a simmer, then stir in the grated parmesan cheese, salt, and black pepper. Whisk continuously until the cheese is fully melted and the sauce is smooth. This should take about 3-4 minutes. Remove from heat.

Step 4: Assemble the Casserole

In a large mixing bowl, combine the roasted spaghetti squash strands with the chicken mixture. Pour the creamy parmesan sauce over everything and stir until well coated.

Transfer the mixture into a lightly greased 9×13-inch baking dish. Sprinkle the top with shredded mozzarella cheese.

Step 5: Bake to Perfection

Reduce oven temperature to 375°F (190°C). Bake the casserole uncovered for 20 minutes, or until the cheese is melted and bubbly.

Step 6: Garnish and Serve

Remove the casserole from the oven and let it sit for 5 minutes before serving. Garnish with chopped fresh basil for a pop of color and flavor. Serve hot and enjoy!

Ingredient Background

One of the standout features of this casserole is its bold Tuscan flavors, which come from a mix of fresh vegetables, creamy sauce, and well-seasoned chicken. Here’s a closer look at some key ingredients:

Spaghetti Squash – The Perfect Pasta Alternative

Spaghetti squash is a fantastic low-carb alternative to traditional pasta. Native to North and Central America, this mild-flavored squash transforms into delicate, noodle-like strands when roasted. Unlike regular pasta, which is high in refined carbs, spaghetti squash is packed with fiber, vitamin C, and antioxidants. It also absorbs flavors exceptionally well, making it the perfect base for a creamy, garlicky Tuscan sauce.

Sun-Dried Tomatoes – A Burst of Intense Flavor

Sun-dried tomatoes are a staple in Italian cuisine and are made by drying fresh tomatoes in the sun or an oven to remove their moisture, leaving behind a rich, slightly tangy, and intensely concentrated tomato flavor. They add depth to this dish, balancing the creamy elements with their naturally sweet and tart taste. These tomatoes are also a great source of lycopene, a powerful antioxidant that supports heart health.

Parmesan Cheese – The Ultimate Umami Booster

Parmesan cheese brings a deep, nutty, and slightly salty flavor to the dish. Aged for months or even years, this cheese is a classic Italian ingredient known for its high umami content, which enhances other flavors in the dish. Parmesan is also a good source of calcium and protein, making it both a tasty and nutritious addition.

Technique Tips for Tuscan Chicken and Spaghetti Squash Casserole

A great casserole comes down to technique. Here are some expert tips to ensure your dish turns out perfectly every time:

Perfectly Roasting Spaghetti Squash

The key to getting the best spaghetti squash texture is proper roasting. Cutting the squash in half and roasting it cut-side down allows it to steam slightly while cooking, making the strands tender but not mushy. If you prefer a firmer texture, roast it at a slightly lower temperature (375°F) for a longer time (45-50 minutes).

Creating a Smooth, Lump-Free Sauce

When making the parmesan cream sauce, whisking constantly is essential. Parmesan can clump if added too quickly, so gradually stirring it into warm cream helps it melt smoothly. If you notice any lumps, a quick whisk over low heat should fix the issue. Additionally, using freshly grated parmesan instead of pre-shredded cheese prevents clumping due to anti-caking agents in store-bought varieties.

Layering for Maximum Flavor

Instead of just mixing everything together and baking, try layering the ingredients. First, spread a thin layer of sauce on the bottom of your baking dish, then add half the spaghetti squash mixture, followed by more sauce, and repeat. This technique ensures every bite is rich and flavorful.

Alternative Presentation Ideas

While this casserole is delicious as-is, you can switch up the presentation to suit different occasions:

Single-Serve Casserole Bowls

For a more elegant presentation, portion the casserole into individual ramekins or small baking dishes before baking. This works great for dinner parties or when serving guests, allowing everyone to have their own mini casserole.

Stuffed Spaghetti Squash Boats

Instead of transferring the mixture to a casserole dish, serve it right in the roasted spaghetti squash shells. Simply scrape the strands while keeping the shell intact, mix with the chicken and sauce, and spoon it back into the squash halves. This creates a stunning restaurant-style presentation and cuts down on dishes.

Topped with a Crispy Parmesan Crust

For a crunchier texture, sprinkle a mix of grated parmesan and crushed almond flour or panko breadcrumbs on top before baking. This gives a crispy, golden topping that contrasts beautifully with the creamy filling.

Freezing and Storing Tuscan Chicken and Spaghetti Squash Casserole

If you love meal prepping, this casserole is an excellent make-ahead option. Here’s how to store it properly:

Refrigerating for Short-Term Storage

After baking, let the casserole cool to room temperature before covering it tightly with foil or transferring it to an airtight container. Store it in the refrigerator for up to 4 days. To reheat, simply bake at 350°F for 15-20 minutes or microwave individual portions.

Freezing for Later Use

For longer storage, you can freeze this casserole. Assemble it as directed but don’t bake it yet. Wrap the entire dish tightly with plastic wrap and foil, then freeze for up to 3 months. When ready to eat, thaw overnight in the refrigerator and bake as usual.

Reheating Without Drying Out

Since spaghetti squash contains natural moisture, reheating can sometimes dry out the dish. To keep it creamy, add a splash of chicken broth or cream before reheating. Covering the dish with foil while reheating helps retain moisture.

Healthier Twist Ideas

Looking for ways to make this dish even healthier? Here are some simple swaps:

Dairy-Free Version

Replace the heavy cream with coconut milk or cashew cream and use nutritional yeast instead of parmesan for a dairy-free, paleo-friendly version.

Lean Protein Swap

Instead of chicken, try using ground turkey or lean ground beef for a heartier twist. You can also use tofu or chickpeas for a vegetarian-friendly version while keeping the Tuscan flavors intact.

Extra Veggies for More Nutrients

Boost the nutritional value by adding more vegetables. Chopped zucchini, mushrooms, or bell peppers blend beautifully into the dish without altering the flavor too much.

Serving Suggestions for Events

This casserole is incredibly versatile and works well for different occasions:

Casual Family Dinner

Serve it alongside a simple side salad with a balsamic vinaigrette and some garlic bread for a complete, balanced meal.

Elegant Dinner Party

Pair this dish with a roasted vegetable platter and a sparkling water with lemon for a refined yet comforting meal that guests will love.

Potluck or Meal Prep

This casserole travels well, making it ideal for potlucks or office lunches. Simply store it in a covered dish and reheat before serving.

Frequently Asked Questions (FAQs)

1. Can I use frozen spinach instead of fresh?

Yes! Just make sure to thaw and squeeze out excess water before adding it to the dish.

2. What can I use instead of spaghetti squash?

Zucchini noodles, cauliflower rice, or even whole wheat pasta can work as alternatives.

3. Can I make this casserole ahead of time?

Absolutely! Assemble it ahead and refrigerate, then bake when ready.

4. Is this dish keto-friendly?

Yes! It’s naturally low in carbs, making it a great keto meal.

5. Can I add mushrooms?

Definitely! Mushrooms add a wonderful umami depth to the dish.

6. What’s the best way to reheat leftovers?

Bake at 350°F or microwave with a splash of broth to keep it moist.

7. Can I make this casserole spicy?

Yes! Add more red pepper flakes or diced jalapeños for heat.

8. What if I don’t like sun-dried tomatoes?

You can swap them for cherry tomatoes or roasted red peppers.

9. Can I use pre-cooked chicken?

Yes, rotisserie or leftover grilled chicken works perfectly.

10. How can I make it extra cheesy?

Mix in extra mozzarella and top with more parmesan before baking.

Conclusion

This Tuscan Chicken and Spaghetti Squash Casserole is a must-try for anyone who loves creamy, comforting flavors but wants a healthier twist. With its rich garlic parmesan sauce, tender chicken, and roasted spaghetti squash, it’s a dish that feels indulgent yet is packed with nutrients. Whether you’re making it for a weeknight meal, meal prepping, or serving it for guests, this casserole is sure to impress.

So why wait? Gather your ingredients and give this Tuscan-inspired dish a try—you won’t regret it!

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